New drugs could help prevent hearing loss
Compared with a normal mouse cochlea (top), cisplatin exposure reduces the number of outer hair cells (middle). But the loss of these cells is prevented by treatment with the CDK2 inhibitor kenpaullone (bottom).
Researchers from St. Jude Children’s Research Hospital have discovered that inhibiting an enzyme called cyclin-dependent kinase 2 (CDK2) protects mice and rats from noise- or drug-induced hearing loss. The study, which will be published March 7 in the Journal of Experimental Medicine, suggests that CDK2 inhibitors prevent the death of inner ear cells, which has the potential to save the hearing of millions of people around the world.
According to the World Health Organization, 360 million people worldwide, including 32 million children, suffer from hearing loss caused by congenital defects or other factors. These factors include infectious disease, use of certain medicines, or exposure to excessive noise. Yet, there are currently no FDA-approved drugs to prevent or treat hearing loss.
A team of researchers led by Dr. Jian Zuo screened over 4,000 drugs for their ability to protect cochlear cells from the chemotherapy agent cisplatin. Cisplatin is used to treat a variety of cancers but causes irreversible hearing loss in up to 70% of patients.
Zuo and colleagues identified multiple compounds that protected cochlear cells from cisplatin, several of which are already approved to treat other conditions. Three of the ten most effective compounds were inhibitors of an enzyme called CDK2. One of these CDK2 inhibitors, kenpaullone, was more effective than four other compounds that are currently in clinical trials for treating hearing loss.
Injecting kenpaullone into the middle ear protected both mice and rats from cisplatin-induced hearing loss. Moreover, kenpaullone also protected the hearing of mice to noise as loud as 100 dB. “Given that 100-dB noise is in the range of noise insults commonly experienced by people in our society, kenpaullone could have significant clinical application in treating noise-induced hearing loss,” says Zuo.
In the case of cisplatin-induced hearing loss, kenpaullone appears to protect hair cells by preventing CDK2 from stimulating the production of toxic reactive oxygen species from the cells’ mitochondria.
“The robust protection conferred by one-time local delivery of kenpaullone suggests that CDK2 inhibitors may transform the clinical prevention and treatment of cisplatin- and noise-induced hearing loss in patients,” Zuo says. “Modifications of the treatment regimens, additional optimization of the delivery methods via the use of hydrogels, and structural modifications of the compounds via medicinal chemistry could ensure even better results with CDK2 inhibitors in treating hearing loss in humans.”
Edited by Ariasun editorial board
for ariasun products online shopping ,click here.
website ariasuniweb net ariasuniportal ariasuni Health Journal Family physician Medical Health Ariasan Elcomp </ em> Elcomp Exhibition </ em> Online Elcomp Therapy Health Electronics Tourism Aryans City Net Soocom Ariasun Soopak Ariasun medipharma Advertisement Reader The requirements Employment Currency Exchange Currency Coin Gold < em> car property land building stock exchange bank Government People Leader Assembly Quran Book Student University Knowledge base Exercise Sima Sound Religion < / em> Life People Hope Work Dread Unemployment youth exercise information technology computer < / em> Hardware Software Computer Server Virtual Tablet < / em> Mobile Zanjan Tehran Iran Germany Greece Georgia Georgia Dubai World Air Space < em> Country Product Finder AriaSun International Group Online Store WikiPharma AriaSun Production Industrial Operations Equip Installation & Investment Air Space International Trading Research Industrial Business Medical Dummy Undoubtedly Health Drug Therapy Health Information Technology & Computer Airlines Tourism Logo Design Sticker Design Advertising Campaign Science & Research News </em > Political News Economic Trade International Stock Market News Medical Tourism & Cultural Heritage Aeronautics & Tourism Sport & Olympic Domain and University The Quran Arts & Culture Industry & Technology Accidents Ladies Currency and Gold Coins Flats Rip’s Web Site Kandasheh Ahwaz Web Site Foot Website Abuse Clean Sean Cinere Live Nature Whats Punababy Mussels Clinic Radarians Man AriaSun Preddies Reservations < Em> Tourists Unemployment youth exercise CityNet PakSaman SooComAriaSun SooPakAriaSun MediPharma AriaSun Kalayab AriaSunBazar AriaSunBazar Medeca MediKala Artists Group AriaSunGroup Web site designing RP Pilgrimage website Historical tours website Web Resident Resorts site Tours website The Pana The Natural Tours Website Kandesheh Ahwaz The Scientific Tour Website Oil & Refineries The Sports Tour Website Gas The Web Tours Water Exposure Tour Site Travel Tour Website Travel Tours The Last-minute Tours Site Tours of the last minute Web-site of the local tours Recreation site Internal tours site Pilgrimage Fun Places Design Web Design City Net Designing a Holiday Resort Pilgrimage Pilgrimage Website designing pilgrimage City Net Pilgrimage Travel </em > Designing Travel Planner Website Designing Travel Places Historic Places Designing Historic Places Historic Places Design Residences Residential Residential Design Residential Residential Design Cultural Places Designing a Web Site for Cultural Places Designing Cultural Places Natural Places Natural Places Designing a natural site Designing a natural website scientific Designing for scientific Designing for scientific sports sports designing sports < Em> Sports Facilities Design Sports Facilities Sport Sport Designing a Sports Center for Extreme Sports Creating places Designing for Exhibition Exhibit places Designing Exhibit Places Designing Exposure Website Web Recreation Recreation Web Design Recreational tours The design of the tourist resorts Pilgrimage Pilgrimage Pilgrimage Pilgrimage Pilgrimage Tours Historic Tours Tour Design Historic Tours Web Tour Design Historical Tours Residential Tours Resorts Tour Design Residential Tour Website Design Cultural Design Cultural Tour Site Cultural Tour Website Natural Designing Natural Tours Designing Natural Tours Web Site Science Designing Scientific Tours Designing Sci-Fi Web Site Designing a Sports Tour Designing a Sports Tour Website Designing a Tours Tour Designing a Touring Web Site Exhibit Exhibit Tour Travel Designing Tours Tour The Last Moment Toure The Last Moment Designing the Last Minute Tours Internal Tours Designing Local Tours Designing a Web Site Tour </em > Foreign Tours Designing a Tours Site Designing a Website for Tours Coastal Work < em> Designing the Coast Guided Tour Urban Designing Urban Tours Urban Touring Sights < Em> Sightseeing Design Sightseeing Web Site Mountaineering Sailing Designing Sailing Tours < Em> Website Designing Sailing Tours Aviation Designing Tours Cruising Cruising ships Creating cruise ship cruises Creating Cruise Cruises Inbound Flights Designing Inbound Flights Foreign Flights Designing a Foreign Airmail Web site Last Minute Flights Web Design Last Minute Deals cheap Website Design Cheap Flights Online Shopping Online Sales Online Selling Website Design Online Shopping Online Store Online Store Design Online Tickets Design an Online Ticket Internet Designing a Web Store Internet Tickets Designing an Internet Ticket > parscoders
Finance & Administration
Soopak Ariasun ( IT )
Sookam Ariasun ( Medical and Veterinary )
Aerospace ( Pad Ariasun )
Manufacture and production ( Rad Ariasun )
Airline and Tourism ( Man Ariasun )
International Commerce ( Mad Ariasun )
Research Center Ariasun ( R&D&C )
Cultural,Satellite and Digital
AriaSun International Group