Paraplegic rats walk and regain feeling after stem cell treatment
The rats show significantly improved mobility and sensory perception, as well as spinal cord healing
Engineered tissue containing human stem cells has allowed paraplegic rats to walk independently and regain sensory perception. The implanted rats also show some degree of healing in their spinal cords. The research, published in Frontiers in Neuroscience, demonstrates the great potential of stem cells — undifferentiated cells that can develop into numerous different types of cells — to treat spinal cord injury.
Spinal cord injuries often lead to paraplegia. Achieving substantial recovery following a complete spinal cord tear, or transection, is an as-yet unmet challenge.
Led by Dr. Shulamit Levenberg, of the Technion-Israel Institute of Technology, the researchers implanted human stem cells into rats with a complete spinal cord transection. The stem cells, which were derived from the membrane lining of the mouth, were induced to differentiate into support cells that secrete factors for neural growth and survival.
The work involved more than simply inserting stem cells at various intervals along the spinal cord. The research team also built a three-dimensional scaffold that provided an environment in which the stem cells could attach, grow and differentiate into support cells. This engineered tissue was also seeded with human thrombin and fibrinogen, which served to stabilize and support neurons in the rat’s spinal cord.
Rats treated with the engineered tissue containing stem cells showed higher motor and sensory recovery compared to control rats. Three weeks after introduction of the stem cells, 42% of the implanted paraplegic rats showed a markedly improved ability to support weight on their hind limbs and walk. 75% of the treated rats also responded to gross stimuli to the hind limbs and tail.
In contrast, control paraplegic rats that did not receive stem cells showed no improved mobility or sensory responses.
In addition, the lesions in the spinal cords of the treated rats subsided to some extent. This indicates that their spinal cords were healing.
While the results are promising, the technique did not work for all implanted rats. An important area for further research will be to determine why stem cell implantation worked in some cases but not others. As the research team notes, “This warrants further investigation to shed light on the mechanisms underlying the observed recovery, to enable improved efficacy and to define the intervention optimal for treatment of spinal cord injury.”
Although the study in itself does not solve the challenge of providing medical treatments for spinal cord injury in humans, it nevertheless points the way to that solution. As Dr. Levenberg puts it: “Although there is still some way to go before it can be applied in humans, this research gives hope.”
Edited by Ariasun editorial board
for ariasun products online shopping ,click here.
Health Journal Family physician Medical Health Ariasan Elcomp </ em> Elcomp Exhibition </ em> Online Elcomp Therapy Health Electronics Tourism Aryans City Net Soocom Ariasun Soopak Ariasun medipharma Advertisement Reader The requirements Employment Currency Exchange Currency Coin Gold < em> car property land building stock exchange bank Government People Leader Assembly Quran Book Student University Knowledge base Exercise Sima Sound Religion < / em> Life People Hope Work Dread Unemployment youth exercise information technology computer < / em> Hardware Software Computer Server Virtual Tablet < / em> Mobile Zanjan Tehran Iran Germany Greece Georgia Georgia Dubai World Air Space < em> Country Product Finder AriaSun International Group Online Store WikiPharma AriaSun Production Industrial Operations Equip Installation & Investment Air Space International Trading Research Industrial Business Medical Dummy Undoubtedly Health Drug Therapy Health Information Technology & Computer Airlines Tourism Logo Design Sticker Design Advertising Campaign Science & Research News </em > Political News Economic Trade International Stock Market News Medical Tourism & Cultural Heritage Aeronautics & Tourism Sport & Olympic Domain and University The Quran Arts & Culture Industry & Technology Accidents Ladies Currency and Gold Coins Flats Rip’s Web Site Kandasheh Ahwaz Web Site Foot Website Abuse Clean Sean Cinere Live Nature Whats Punababy Mussels Clinic Radarians Man AriaSun Preddies Reservations < Em> Tourists Unemployment youth exercise CityNet PakSaman SooComAriaSun SooPakAriaSun MediPharma AriaSun Kalayab AriaSunBazar AriaSunBazar Medeca MediKala Artists Group AriaSunGroup Web site designing RP Pilgrimage website Historical tours website Web Resident Resorts site Tours website The Pana The Natural Tours Website Kandesheh Ahwaz The Scientific Tour Website Oil & Refineries The Sports Tour Website Gas The Web Tours Water Exposure Tour Site Travel Tour Website Travel Tours The Last-minute Tours Site Tours of the last minute Web-site of the local tours Recreation site Internal tours site Pilgrimage Fun Places Design Web Design City Net Designing a Holiday Resort Pilgrimage Pilgrimage Website designing pilgrimage City Net Pilgrimage Travel </em > Designing Travel Planner Website Designing Travel Places Historic Places Designing Historic Places Historic Places Design Residences Residential Residential Design Residential Residential Design Cultural Places Designing a Web Site for Cultural Places Designing Cultural Places Natural Places Natural Places Designing a natural site Designing a natural website scientific Designing for scientific Designing for scientific sports sports designing sports < Em> Sports Facilities Design Sports Facilities Sport Sport Designing a Sports Center for Extreme Sports Creating places Designing for Exhibition Exhibit places Designing Exhibit Places Designing Exposure Website Web Recreation Recreation Web Design Recreational tours The design of the tourist resorts Pilgrimage Pilgrimage Pilgrimage Pilgrimage Pilgrimage Tours Historic Tours Tour Design Historic Tours Web Tour Design Historical Tours Residential Tours Resorts Tour Design Residential Tour Website Design Cultural Design Cultural Tour Site Cultural Tour Website Natural Designing Natural Tours Designing Natural Tours Web Site Science Designing Scientific Tours Designing Sci-Fi Web Site Designing a Sports Tour Designing a Sports Tour Website Designing a Tours Tour Designing a Touring Web Site Exhibit Exhibit Tour Travel Designing Tours Tour The Last Moment Toure The Last Moment Designing the Last Minute Tours Internal Tours Designing Local Tours Designing a Web Site Tour </em > Foreign Tours Designing a Tours Site Designing a Website for Tours Coastal Work < em> Designing the Coast Guided Tour Urban Designing Urban Tours Urban Touring Sights < Em> Sightseeing Design Sightseeing Web Site Mountaineering Sailing Designing Sailing Tours < Em> Website Designing Sailing Tours Aviation Designing Tours Cruising Cruising ships Creating cruise ship cruises Creating Cruise Cruises Inbound Flights Designing Inbound Flights Foreign Flights Designing a Foreign Airmail Web site Last Minute Flights Web Design Last Minute Deals cheap Website Design Cheap Flights Online Shopping Online Sales Online Selling Website Design Online Shopping Online Store Online Store Design Online Tickets Design an Online Ticket Internet Designing a Web Store Internet Tickets Designing an Internet Ticket > parscoders
Finance & Administration
Soopak Ariasun ( IT )
Sookam Ariasun ( Medical and Veterinary )
Aerospace ( Pad Ariasun )
Manufacture and production ( Rad Ariasun )
Airline and Tourism ( Man Ariasun )
International Commerce ( Mad Ariasun )
Research Center Ariasun ( R&D&C )
Cultural,Satellite and Digital
AriaSun International Group